GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs783540 | 1 | rs11637433 | chr15:83321336 | FAM154B | chr15:82555152-82577265:+ | 0.14 | 4.15 | 3.52E-5 | Schizophrenia |
| BRCA | cis | rs783540 | 1 | rs11637433 | chr15:83321336 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | 0.1 | 3.67 | 0.000257 | Schizophrenia |
| BRCA | cis | rs11638815 | 1 | rs11638815 | chr15:83352282 | GOLGA6L10 | chr15:82633124-82637131:-;chr15 | 0.1 | 3.38 | 0.000751 | Lipoprotein-associated phospholipase A2 activity change in response to statin therapy |
| BRCA | cis | rs11638815 | 1 | rs11638815 | chr15:83352282 | GOLGA6L9 | chr15:82711895-82731584:+;chr15 | 0.2 | 6.15 | 1.08E-9 | Lipoprotein-associated phospholipase A2 activity change in response to statin therapy |
| BRCA | cis | rs10043228 | 1 | rs116434420 | chr5:115582971 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 4.6 | 4.75E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs1799922 | 1 | rs11653 | chr7:128409580 | OPN1SW | chr7:128412545-128415844:- | 0.16 | 3.94 | 8.56E-5 | Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth) |
| BRCA | cis | rs2840044 | 1 | rs11653310 | chr17:33893378 | SLFN12L | chr17:33801926-33864880:- | -0.08 | -4.69 | 3.06E-6 | Response to radiotherapy in cancer (late toxicity) |
| BRCA | cis | rs2840044 | 1 | rs11656138 | chr17:33910218 | SLFN12L | chr17:33801926-33864880:- | 0.09 | 4.86 | 1.34E-6 | Response to radiotherapy in cancer (late toxicity) |
| BRCA | cis | rs1808579 | 1 | rs11663558 | chr18:21133937 | NPC1 | chr18:21108363-21166581:- | 0.14 | 4.34 | 1.53E-5 | Body mass index |
| BRCA | cis | rs11174436 | 1 | rs116644267 | chr12:62760067 | FAM19A2 | chr12:62102043-62653925:- | 0.2 | 4.05 | 5.54E-5 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs3760982 | 1 | rs11665924 | chr19:44286982 | ZNF155 | chr19:44488355-44502477:+ | -0.14 | -3.77 | 0.00017 | Breast cancer |
| BRCA | cis | rs3760982 | 1 | rs11665924 | chr19:44286982 | ZNF404 | chr19:44376516-44384288:- | -0.22 | -6.04 | 2.12E-9 | Breast cancer |
| BRCA | cis | rs2287838 | 1 | rs11667192 | chr19:9975970 | OLFM2 | chr19:9964395-10047070:- | 0.17 | 5.8 | 8.56E-9 | Sleep duration |
| BRCA | cis | rs1975174 | 1 | rs11668269 | chr19:22513960 | ZNF98 | chr19:22573899-22605148:- | 0.14 | 3.83 | 0.000136 | Telomere length |
| BRCA | cis | rs3760982 | 1 | rs11669175 | chr19:44289824 | LYPD5 | chr19:44300080-44324808:- | -0.13 | -3.73 | 0.000199 | Breast cancer |